Genetic Influences on Brain Gene Expression in Rats Selected for Tameness and Aggression

Inter-individual differences in many behaviors are partly due to genetic differences, but the identification of the genes and variants that influence behavior remains challenging. Here, we studied an F2 intercross of two outbred lines of rats selected for tame and aggressive behavior towards humans for more than 64 generations. By using a mapping approach that is able to identify genetic loci segregating within the lines, we identified four times more loci influencing tameness and aggression than by an approach that assumes fixation of causative alleles, suggesting that many causative loci were not driven to fixation by the selection. We used RNA sequencing in 150 F2 animals to identify hundreds of loci that influence brain gene expression. Several of these loci colocalize with tameness loci and may reflect the same genetic variants. Through analyses of correlations between allele effects on behavior and gene expression, differential expression between the tame and aggressive rat selection lines, and correlations between gene expression and tameness in F2 animals, we identify the genes Gltscr2, Lgi4, Zfp40 and Slc17a7 as candidate contributors to the strikingly different behavior of the tame and aggressive animals

Overview of the current use of levosimendan in France: a prospective observational cohort study

Abstract Background Following the results of randomized controlled trials on levosimendan, French health authorities requested an update of the current use and side-effects of this medication on a national scale. Method The France-LEVO registry was a prospective observational cohort study reflecting the indications, dosing regimens, and side-effects of levosimendan, as well as patient outcomes over a year. Results The patients included ( n = 602) represented 29.6% of the national yearly use of levosimendan in France. They were treated for cardiogenic shock ( n = 250, 41.5%), decompensated heart failure ( n = 127, 21.1%), cardiac surgery-related low cardiac output prophylaxis and/or treatment ( n = 86, 14.3%), and weaning from veno-arterial extracorporeal membrane oxygenation ( n = 82, 13.6%). They received 0.18 ± 0.07 µg/kg/min levosimendan over 26 ± 8 h. An initial bolus was administered in 45 patients (7.5%), 103 (17.1%) received repeated infusions, and 461 (76.6%) received inotropes and or vasoactive agents concomitantly. Hypotension was reported in 218 patients (36.2%), atrial fibrillation in 85 (14.1%), and serious adverse events in 17 (2.8%). 136 patients (22.6%) died in hospital, and 26 (4.3%) during the 90-day follow-up. Conclusions We observed that levosimendan was used in accordance with recent recommendations by French physicians. Hypotension and atrial fibrillation remained the most frequent side-effects, while serious adverse event potentially attributable to levosimendan were infrequent. The results suggest that this medication was safe and potentially associated with some benefit in the population studied

Simulation numérique et conception des structures de grands navires

La simulation numérique joue un rôle croissant dans la conception des navires à côté des ou associée aux approches réglementaires édictées par les sociétés de classification. Ce texte, non exhaustif, veut illustrer les tendances actuelles et les difficultés rencontrées dans l'approche simulation numérique. Celles-ci sont de plusieurs ordres : problèmes de modélisation liés à la taille des structures et à la nécessité d'une approche multi-échelle, problèmes de méthodologie liés à la complexité de l'environnement, problèmes de couplage fluides structures. Enfin ces études doivent se dérouler dans un temps extrêmement court, avec des informations qui se précisent au cours du déroulement de l'étude, informations entachées d'incertitudes et de dispersions. Les grands codes éléments finis généralistes disponibles sur le marché sont en général utilisés, associés à des outils et développements spécifiques si nécessaire, dans des chaînes de calcul plus ou moins intégrées. Les situations extrêmes ou accidentelles font l'objet d'études assez sophistiquées, nécessitant un travail d'interprétation important

Evaluation de la pertinence du diagnostic et de l' estimation de la gravité en régulation médicale au SAMU 972 du CHU de Fort-de-France

FORT-DE-FRANCE-CHRU-BU (972332102) / SudocBORDEAUX2-BU Santé (330632101) / SudocABYMES-CHRUPPA-BU (971202102) / SudocPARIS-BIUM (751062103) / SudocSudocFranceF

Enquête prospective sur la prise en charge des hypoglycémies sévères au SAMU-SMUR du CHU de Fort-De-France

Résumé français : notice = 7Ko MAXIMUM : résumé trop long empêche la validation : longueur = 1700 caractéresLE KREMLIN-B.- PARIS 11-BU Méd (940432101) / SudocPARIS-BIUM (751062103) / SudocSudocFranceF

Le syndrome drépanocytaire majeur aux urgences en 1999 à La Martinique (analyse rétrospective à partir de 68 dossiers médicaux de 49 patients consultant dans les trois services d'urgence de Martinique entre le 1er juin 1999 et le 31 décembre 1999)

BREST-BU Médecine-Odontologie (290192102) / SudocPARIS-BIUM (751062103) / SudocSudocFranceF

Evaluation de la douleur en régulation médicale au SAMU-Centre 15 du CHU de Fort de France

BORDEAUX2-BU Santé (330632101) / SudocPARIS-BIUM (751062103) / SudocSudocFranceF

As paixões antigas e medievais : teorias et criticas dos paixões

Traduction de : Théories et critiques des passions. 1, Les passions antiques et médiévales (2003)Traduction de : Théories et critiques des passions. 1, Les passions antiques et médiévales (2003)"As paixões têm uma longa história na filosofia, como na política, no teatro e na religião. Sob a aparente continuidade dos termos, essa história é feita não só de rupturas, mas também de deslocamentos, de retomadas e de controvérsias sobre as heranças. Exemplos, referências e discussões tópicas reaparecem regularmente em novos contextos que lhes dão sentidos diferentes e direções às vezes opostas

Science et éthique

Dagognet François, Haarscher Guy, Besnier Jean-Michel. Science et éthique. In: Raison présente, n°97, 1er trimestre 1991. Questions à la science. pp. 59-88